Pipeline

A unique understanding of time-dependent biological processes informs everything we innovate for the treatment of chronic neurologic disorders. We continue to search for time-dependent patterns in diseases to reshape medicines and drive improved clinical outcomes for people in need.

Our medicines are timed for the benefit of patients.

ADS-5102 (amantadine) extended-release capsules

Multiple Sclerosis: Walking Impairment

Multiple sclerosis (MS) is a chronic autoimmune-mediated disorder that affects approximately 400,000 people in the United States.1 Walking impairment is a central feature of MS progression.2,3,4 The reported prevalence of impaired mobility due to MS ranges from 50% to over 90% of patients.1 As also reported in Parkinson’s disease, dysregulation of the NMDA receptor has been associated with the symptomology of MS,5 therefore symptoms may be improved by modulating overactivated NMDA receptor signaling. In addition, the impact of walking impairment and related symptoms (eg, fatigue, depression, and cognition) is most profound during the daytime when MS patients are engaged in activities of daily living.6,7 As a result, an effective treatment should provide relief beginning in the morning, and be sustained throughout the day, while not disrupting sleep.

ADS-5102, a high-dose amantadine investigational agent taken once-daily at bedtime, was designed to provide a slow initial rate-of-rise in drug concentrations and a delayed time to the maximum concentration.

We completed a Phase 2 proof-of-concept study evaluating ADS-5102 in patients with MS who have walking impairment. In the study, patients treated with ADS-5102 showed a significant improvement in walking speed as assessed by the Timed 25 Foot Walk (T25FW) test and an improvement in the Timed Up and Go (TUG). In addition, ADS-5102 was generally well tolerated.

Based on the positive Phase 2 data, we’ve initiated the first Phase 3 study in MS patients with walking impairment in April. Our Phase 3 program is planned to consist of two Phase 3 studies, a pivotal efficacy and safety study, and an open label safety study. We are also completing non-clinical studies to support the approval in this multiple sclerosis population. If the first pivotal Phase 3 study is successful, we intend to meet with the FDA to confirm the filing requirements for this supplemental NDA.

ADS-5102 References: 1. Sutliff, M. H. Contribution of impaired mobility to patient burden in multiple sclerosis. Curr Med Res Opin; 2010 26(1): 109-119. 2. Kurtzke, J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) and Form. Neurology; 1983 33(11):1444-1452. 3. Cohen, R. A., H. R. Kessler, et al. The Extended Disability Status Scale (EDSS) as a predictor of impairments of functional activities of daily living in multiple sclerosis. J Neurol Sci; 1993 115(2):132-135. 4. Hobart, J. C., A. Riazi, et al. Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12). Neurology; 2003 60(1):31-36. 5. Rossi, S., V. Studer, et al. Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One; 2013 8(6):e67357. 6. Cohen, R.A., and M. Fisher. Amantadine Treatment of Fatigue Associated with Multiple Sclerosis. Arch Neurol; 1989; 46:676-680. 7. Socie, M.J., et. al. Gait variability and disability in multiple sclerosis. Gait & Posture; 2013 38:1-55.

Director, Corporate and Product Communications

The Director, Corporate and Product Communications at Adamas will support the development and execution of Adamas’ Corporate and Product communications strategies, develop positioning and core messaging, execute tactically, build relationships with key channels, and effectively communicate about the Company and brands to constituencies. Reporting to the VP, Communications and Engagement this person will be a main contact for advocacy relationships, forging partnerships and leading on strategic collaborations. The Director will work closely with Product Brand team(s) to develop and and execute effective communications, media and PR activities to support brand strategy and positioning, including corporate communications around scientific and medical milestones.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Neurology Account Specialist, Atlanta GA

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Neurology Account Specialist, Chicago IL

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

 

Senior Accountant

The Senior Accountant is responsible for performing daily accounting operations including preparation of journal entries, account reconciliations, financial statement analysis and ad hoc projects. The Senior accountant will be responsible for cash, payroll, and equity related accounting. The Senior Accountant will also manage and coordinate the payroll performed by our third-party service provider to ensure accurate and timely processing of payroll in Workday for approximately 200 multi-state employees. Additionally, this individual will routinely partner with others across multiple functions ensuring proper alignment with policies, internal controls (SOX 404) and compliance with US GAAP. This position reports to the Senior Manager, Accounting and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, Commercial IT

The Senior Director, Commercial IT is responsible for serving as strategic interface with Commercial and Medical affairs organizations. Individual in this role is responsible for developing relationships with business stakeholders and serve as trusted technology advisor in addition to leading Commercial IT function and staff. Senior Director is required to maintain an understanding of Pharmaceutical commercial business processes, Commercial/Medical data & technology roadmap, design solutions, implement systems, and manage operational support for commercial IT systems. This person will be responsible for understanding and coordinating with the other IT business partners, especially across Commercial IT teams around other initiatives aligned to common capabilities such as business intelligence and master data management to deliver value added services in various business function.

Individual in this role will represent the technology organization as the primary point of contact with the Commercial & Medical Affairs organization and accountable for all technology related issues and opportunities and address them thru the engagement and support of cross functional team.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, IT (Infrastructure, Operations and Security)

The Sr. Director, IT is a senior level individual to lead and execute the strategy for IT infrastructure, help desk customer support, network operations and security. Individual in this role is responsible for leading IT function and staff that provides the following support to the enterprise: helpdesk and customer service, data center operations, security operations, server OS operations, network operations; storage operations and system maintenance and monitoring. He/She has overall accountability for team decisions, management, and results. Provides direction, coaches, develops, and mentors leaders within the Helpdesk and Network teams and outside those groups in addition to hands-on support as needed. He/she is an advocate for Adamas’ total information security needs and is responsible for the development and delivery of a comprehensive risk based information security strategy to optimize the security posture of the company.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.