Pipeline

At Adamas, our belief that our medicines should be clinically differentiated and make a difference to our patients’ lives informs our decisions. As a fully-integrated pharmaceutical company, we maintain a dedicated focus on developing and delivering innovative new medicines for neurological diseases by leveraging our leadership and subject matter expertise.

 

ADS-5102 (GOCOVRI) extended-release capsules

Multiple Sclerosis: Walking Impairment

Multiple sclerosis (MS) is a chronic autoimmune-mediated disorder that affects approximately 1 million people in the United States.1 Among the MS patients in the US, nearly 270,000 have walking impairment, which is present throughout the day.2 Walking impairment is a central feature of MS progression.3 Walking impairment in MS remains an area of high unmet need, as there is only one approved product on the market for this indication.

Adamas is evaluating ADS-5102 (amantadine) extended release capsules, an investigational agent, taken once-daily at bedtime, in multiple sclerosis patients with walking impairment. Results from the Phase 3 INROADS study showed that subjects taking 274 mg ADS-5102 had a statistically significant improvement demonstrated by response rate of 21.1% compared to 11.3% taking placebo (p=0.01).* Additionally, the response rate for subjects taking 137 mg ADS-5102 was 17.6% (p=0.08). The most common adverse events were: peripheral edema, dry mouth, fall, constipation, UTI, and insomnia. The reported adverse events associated with ADS-5102 in this study were dose-dependent and consistent with the known safety profile of amantadine. The open-label extension study of ADS-5102 in this population is ongoing.

Adamas expects to engage with the FDA in the first half of 2020 to discuss a potential regulatory pathway.

ADS-5102 is approved by the FDA for the treatment of dyskinesia in patients with Parkinson’s disease receiving levodopa-based therapy and is marketed as GOCOVRI® (amantadine) extended release capsules. GOCOVRI is not FDA-approved for the treatment of multiple sclerosis patients with walking impairment. For more information about GOCOVRI, click here.

*Response was defined as at least a 20% improvement in walking speed from baseline to 12 weeks post-treatment, as measured by the Timed 25 Foot Walk test.

ADS-5102 References:
1. Wallin et al. 2019 applied 2010-2017, downward adjustment for epi growth from 2018 onward based on DRG input 2019-4-30.
2. Sidovar MF, Limone BL, Lee S, et al. Mapping the 12-item multiple sclerosis walking scale to the EuroQol 5-dimension index measure in North American multiple sclerosis patients. BMJ Open 2013.
3. Cohen, R. A., H. R. Kessler, et al. The Extended Disability Status Scale (EDSS) as a predictor of impairments of functional activities of daily living in multiple sclerosis. J Neurol Sci; 1993 115(2):132-135.

Director, Regulatory Affairs

.The Director, Regulatory Affairs will play a key role in generating the necessary documentation and interacting with regulatory agencies for successful regulatory submissions supporting the Company’s programs. Primary responsibilities include providing expertise in translating regulatory requirements into practical, workable plans, preparation of critical submission documentation and communications with business partners and FDA for assigned projects. Responsibilities include participation in Adamas’ general regulatory affairs and regulatory compliance functions. This position may manage the activities of other regulatory affairs staff or contract regulatory support in the performance of the duties outlined below. This position based in Emeryville, CA and reports to the Vice President, Regulatory Affairs.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Sales Analytics and Operations

The Director, Sales Analytics and Operations partners with the Commercial Organization to drive and measure performance by providing subject matter expertise, leadership and insights with a primary focus on Reporting, Incentive Compensation, and CRM/DW/MDM. This position reports to the Senior Director, Business Analytics & Sales Operations and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Neurology Account Specialist, Rochester/Buffalo NY

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

 

Regional Business Director, Maryland

The Regional Business Director will hire, develop and lead a high performing regional sales team of Neurology Sales Specialists (NAS). This position will help develop and then execute commercial strategies to meet Adamas national and regional business objectives. This is a field based position with corporate headquarters in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

 

Senior Medical Science Liaison - Southeast

The Senior Medical Science Liaison is responsible for conducting medical/scientific interactions and for supporting internal activities related to medical communications, medical information and clinical research. This position reports to the Director, Medical Science Liaison and is field based with a corporate headquarters in Emeryville, California.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, Market Access

The Senior Director, Market Access is a hands-on senior leader responsible for providing strategic leadership and direction of all reimbursement and payer access for GOCOVRI® in Parkinson’s Disease. The Senior Director, Market Access will also provide strategic insight to assist with the launch preparation for Adamas pipeline products. This position will oversee development and maintenance of relationships with insurance/managed care organizations and payer negotiations to ensure access to GOCOVRI® for clinically appropriate patients. As a member of the broader commercial team, this position will work across the organization to ensure reimbursement and payer strategy are implemented in alignment with project team deliverables that directly support the execution of the brand plan. This position reports to the Vice President, Market Access and Distribution and is based in Emeryville, CA.

Responsibilities:

Qualifications:

Skills:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Vice President, Market Access & Distribution

The VP, Market Access & Distribution is responsible for leading the commercial operations for the organization that directly supports the commercial success of GOCOVRI ® this includes; providing strategic leadership and direction of all product distribution, reimbursement and payer access; ensuring effective business analytics and systems; delivering strategic insights for launch planning activities, as well as working closely with the New Product Discovery team in the assessment and selection of new products and expansion indications. As a member of the commercial leadership team, this position will work across the organization to ensure commercial operations support is in alignment with project team deliverables that support the execution of commercial launch plans. This position reports to the Chief Commercial Officer and is based in Emeryville, CA.

Responsibilities:

Qualifications:

Senior VP Additional Experience/Considerations:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.