Pipeline

A unique understanding of time-dependent biological processes informs everything we innovate for the treatment of chronic neurologic disorders. We continue to search for time-dependent patterns in diseases to reshape medicines and drive improved clinical outcomes for people in need.

Our medicines are timed for the benefit of patients.

ADS-5102 (amantadine) extended-release capsules

Multiple Sclerosis: Walking Impairment

Multiple sclerosis (MS) is a chronic autoimmune-mediated disorder that affects approximately 400,000 people in the United States.1 Walking impairment is a central feature of MS progression.2,3,4 The reported prevalence of impaired mobility due to MS ranges from 50% to over 90% of patients.1 As also reported in Parkinson’s disease, dysregulation of the NMDA receptor has been associated with the symptomology of MS,5 therefore symptoms may be improved by modulating overactivated NMDA receptor signaling. In addition, the impact of walking impairment and related symptoms (eg, fatigue, depression, and cognition) is most profound during the daytime when MS patients are engaged in activities of daily living.6,7 As a result, an effective treatment should provide relief beginning in the morning, and be sustained throughout the day, while not disrupting sleep.

ADS-5102, a high-dose amantadine investigational agent taken once-daily at bedtime, was designed to provide a slow initial rate-of-rise in drug concentrations and a delayed time to the maximum concentration.

We completed a Phase 2 proof-of-concept study evaluating ADS-5102 in patients with MS who have walking impairment. In the study, patients treated with ADS-5102 showed a significant improvement in walking speed as assessed by the Timed 25 Foot Walk (T25FW) test and an improvement in the Timed Up and Go (TUG). In addition, ADS-5102 was generally well tolerated.

Based on the positive Phase 2 data, we’ve initiated the first Phase 3 study in MS patients with walking impairment in April. Our Phase 3 program is planned to consist of two Phase 3 studies, a pivotal efficacy and safety study, and an open label safety study. We are also completing non-clinical studies to support the approval in this multiple sclerosis population. If the first pivotal Phase 3 study is successful, we intend to meet with the FDA to confirm the filing requirements for this supplemental NDA.

ADS-5102 References: 1. Sutliff, M. H. Contribution of impaired mobility to patient burden in multiple sclerosis. Curr Med Res Opin; 2010 26(1): 109-119. 2. Kurtzke, J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) and Form. Neurology; 1983 33(11):1444-1452. 3. Cohen, R. A., H. R. Kessler, et al. The Extended Disability Status Scale (EDSS) as a predictor of impairments of functional activities of daily living in multiple sclerosis. J Neurol Sci; 1993 115(2):132-135. 4. Hobart, J. C., A. Riazi, et al. Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12). Neurology; 2003 60(1):31-36. 5. Rossi, S., V. Studer, et al. Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One; 2013 8(6):e67357. 6. Cohen, R.A., and M. Fisher. Amantadine Treatment of Fatigue Associated with Multiple Sclerosis. Arch Neurol; 1989; 46:676-680. 7. Socie, M.J., et. al. Gait variability and disability in multiple sclerosis. Gait & Posture; 2013 38:1-55.

Benefits and HR Analyst

The Benefits and HR Analyst is directly responsible for the ongoing operation of health, welfare, leave and 401(k) programs and policies. They are also charged with maintaining accurate HR and Benefits data and records in the Workday HRIS system. Further, this role supports, in an analytical role, the annual compensation analysis, planning and administration cycles as well as the processes that accomplish ad hoc employee job and compensation changes. This role is based in Emeryville, CA and reports to the Director, Total Rewards and HR Systems.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Clinical Program Manager

The Clinical Program Manager will be responsible for developing, managing and implementing single and multi-site clinical trials. This position is based in Emeryville, CA and reports to the Senior Director, Project Management.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Sales Analytics and Operations

The Director, Sales Analytics and Operations partners with the Commercial Organization to drive and measure performance by providing subject matter expertise, leadership and insights with a primary focus on Reporting, Incentive Compensation, and CRM/DW/MDM. This position reports to the Senior Director, Business Analytics & Sales Operations and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Neurology Account Specialist, Columbia SC

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

 

Neurology Account Specialist, Salt Lake City UT

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Regional Business Director, Maryland

The Regional Business Director will hire, develop and lead a high performing regional sales team of Neurology Sales Specialists (NAS). This position will help develop and then execute commercial strategies to meet Adamas national and regional business objectives. This is a field based position with corporate headquarters in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

 

Senior Director, Business Analytics and Sales Operations

The Senior Director, Business Analytics and Sales Operations supports the Adamas commercial organization decision-making by leading commercial analytics processes, delivering strategic insights for GOCOVRI®, and working closely with the New Product Discovery team in the assessment and selection of new products and expansion indications. The individual will participate actively in commercial planning efforts by providing objective, in-depth analyses on current and future markets, develop customers insights, lead primary market research, and be responsible for competitor assessments. Additionally, the individual will lead the Director, Sales Analytics and Operations who is responsible for partnering with the Commercial Organization to drive and measure performance with a primary focus on Field Reporting, Incentive Compensation, and CRM/DW/MDM. This position reports to the Vice President, Commercial Operations and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Senior Medical Science Liaison - Southeast

The Senior Medical Science Liaison is responsible for conducting medical/scientific interactions and for supporting internal activities related to medical communications, medical information and clinical research. This position reports to the Director, Medical Science Liaison and is field based with a corporate headquarters in Emeryville, California.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Senior Medical Science Liaison - West

The Senior Medical Science Liaison is responsible for conducting medical/scientific interactions and for supporting internal activities related to medical communications, medical information and clinical research. This position reports to the Director, Medical Science Liaison and is field based with a corporate headquarters in Emeryville, California.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, IT (Infrastructure, Operations and Security)

The Sr. Director, IT is a senior level individual to lead and execute the strategy for IT infrastructure, help desk customer support, network operations and security. Individual in this role is responsible for leading IT function and staff that provides the following support to the enterprise: helpdesk and customer service, data center operations, security operations, server OS operations, network operations; storage operations and system maintenance and monitoring. He/She has overall accountability for team decisions, management, and results. Provides direction, coaches, develops, and mentors leaders within the Helpdesk and Network teams and outside those groups in addition to hands-on support as needed. He/she is an advocate for Adamas’ total information security needs and is responsible for the development and delivery of a comprehensive risk based information security strategy to optimize the security posture of the company.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, Market Access

The Senior Director, Market Access is a hands-on senior leader responsible for providing strategic leadership and direction of all reimbursement and payer access for GOCOVRI® in Parkinson’s Disease. The Senior Director, Market Access will also provide strategic insight to assist with the launch preparation for Adamas pipeline products. This position will oversee development and maintenance of relationships with insurance/managed care organizations and payer negotiations to ensure access to GOCOVRI® for clinically appropriate patients. As a member of the broader commercial team, this position will work across the organization to ensure reimbursement and payer strategy are implemented in alignment with project team deliverables that directly support the execution of the brand plan. This position reports to the Vice President, Market Access and Distribution and is based in Emeryville, CA.

Responsibilities:

Qualifications:

Skills:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Vice President, Market Access & Distribution

The VP, Market Access & Distribution is responsible for leading the commercial operations for the organization that directly supports the commercial success of GOCOVRI ® this includes; providing strategic leadership and direction of all product distribution, reimbursement and payer access; ensuring effective business analytics and systems; delivering strategic insights for launch planning activities, as well as working closely with the New Product Discovery team in the assessment and selection of new products and expansion indications. As a member of the commercial leadership team, this position will work across the organization to ensure commercial operations support is in alignment with project team deliverables that support the execution of commercial launch plans. This position reports to the Chief Commercial Officer and is based in Emeryville, CA.

Responsibilities:

Qualifications:

Senior VP Additional Experience/Considerations:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Vice President, Sales

The Vice President, Sales will be responsible for leading the national sales organization for Adamas. This position will be expected to play a hands-on role in developing and executing the company’s sales strategies, conducting regular business reviews, overseeing sales management, providing input into incentive compensation programs, and developing effective sales coaching and communications plans. Additionally, this position will be responsible for establishing and maintaining relationships with key customers, accounts and collaborating with internal stakeholders. This position reports to the Chief Commercial Officer and is based in Emeryville, CA.

Responsibilities:

Qualifications:

Skills:

Senior VP Additional Experience/Considerations:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.