ADS-4101 is an investigational high-dose lacosamide, to be taken once-daily at bedtime. Lacosamide is an anti-epilepsy active ingredient previously approved by the U.S. Food and Drug Administration (FDA) and currently marketed by UCB as VIMPAT® (lacosamide).

Epilepsy affects an estimated 2.2 million Americans, of which 60% have partial onset seizures. Monotherapy treatment of partial seizures is effective in approximately 60% of patients, leaving the remainder of patients to require adjunctive treatment with one or more additional anticonvulsant therapies. There are limited data on the temporal distribution of seizures over the 24-hour day. However, data from published studies and from a study conducted by Adamas suggest that seizures occur in a diurnal pattern, characterized by a peak between 8 AM and 4 PM, and lowest between midnight and 8 AM. Thus, by matching the timing pattern of seizures to the concentration of the anti-epileptic drug, with a higher drug concentration during the day and lower drug concentration during the night, may enable improved seizure control.

Clinical studies of lacosamide have demonstrated dose limitations due to dizziness immediately following administration. We hypothesized the dizziness associated with higher doses might be in part attributed to the rapid initial rate-of-rise in drug concentration. Adamas scientists confirmed this time-dependent effect through in vivo modelling and pre-clinical experiments, showing that tolerability was dependent on rate -of-rise of drug concentration and not on maximum concentrations (Cmax).

We designed ADS-4101 to have an [attenuated/ tempered] initial rate-of-rise in lacosamide concentrations, to potentially improve the adverse event profile. This slow initial rise, enables a higher once-daily nighttime dose, resulting in a higher daytime concentration that may be more effective for patients then VIMPAT.

The data from a Phase 1 study of 24 healthy volunteers showed that a single 400 mg dose of ADS-4101 have improved tolerability compared to the equivalent dose of VIMPAT (lacosamide) immediate-release (IR) tablets. The data also demonstrated that ADS-4101 exhibited the desired pharmacokinetic properties, namely a reduced initial rate-of-rise and prolonged time to maximum drug concentration (Tmax) appropriate for nighttime dosing.

We are currently conducting a multi-dose Phase 1b study designed to evaluate the tolerability and pharmacokinetic profile of three ascending doses of ADS-4101 (up to 600 mg/day) taken once-daily at bedtime compared to ascending doses of twice daily VIMPAT tablets in 24 healthy volunteers. Topline data from the study is expected in the third quarter of 2017.

Brand Team Leader / Sr. Director, Marketing

The Brand Team Leader / Senior Director, Marketing will be responsible for leading the ADS-5102 Brand Team, managing all aspects of marketing and launch of Adamas’ lead product, from pre-commercialization through commercialization.   Additionally, this position oversees marketing campaigns and initiatives and will collaborate with internal stakeholders to ensure that such are implemented in alignment with product goals and objectives. Additionally, this position oversees marketing campaigns and initiatives and will collaborate with internal and external stakeholders to ensure that plans are implemented in alignment with product goals and objectives. The Brand Team Leader / Senior Director, Marketing will report to the Vice President, Marketing and is based in Emeryville, CA.

Specific Responsibilities:

Qualifications:

Competencies:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Corporate Controller

The Corporate Controller will lead the Accounting function of Adamas Pharmaceuticals, Inc. The position has overall responsibility for general ledger accounting, commercial accounting, payroll, accounts payable, accounts receivable, and tax. The Corporate Controller will partner with the Director, SEC Reporting on SEC filings and internal control related matters. This position reports to the Chief Accounting Officer and is based in Emeryville, California.

Specific responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title “Clinical Program Manager” in the subject line. Principals only, no recruiters please.

Desktop Engineer, Information Technology

The Desktop Engineer is responsible for developing, deploying, and managing end user’s systems security, automation, software deployment, software patch remediation and device management in addition to providing escalated helpdesk support to internal users. This position will be tasked with creating functional deliverables, such as; testing plans/scripts, creating training plans and on-boarding manuals, identifying gaps, and providing solutions to IT related matters. This position reports to the Senior Manager, IT Operations and is located in Emeryville, California.

Specific Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Director, Quality Assurance

The Director, Quality Assurance is responsible for all aspects quality assurance and GxP compliance. The Director, Quality Assurance will establish quality plans and policies and report to Quality Management on a regular basis on compliance activities and findings. This position will design, implement and maintain QA and compliance programs and infrastructure including a SOP system, training program, and perform internal and external audits. The Director, Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance in a GxP international regulatory environment. This position will serve as an in-house advisor on GxP compliance and report to the Vice President, Quality Assurance and is based in Emeryville, CA.

Specific Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Manager / Senior Manager, Commercial Finance (Financial Planning and Analysis)

The Manager/ Senior Manager, Commercial Finance (FP&A) is primarily responsible for providing strategic and financial leadership to the organization’s Commercial function. The role will focus on the analytics that support strategic financial planning, budgets, forecasting, monthly close support, and project management. The role will be a hands-on resource to senior management, project/brand leads, and department heads. This position reports to the Sr. Director, FP&A and is based in Emeryville, CA.

Specific Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Medical Science Liaison

The Medical Science Liaison (MSL) is responsible for conducting medical/scientific interactions and for supporting internal activities related to medical communications, medical information and clinical research.  This position reports to the Director, Medical Science Liaison and is a field based position with a corporate headquarters in Emeryville, California.

Specific Responsibilities:

Qualifications:

To apply for this position, please click here. Principals only, no recruiters please.

Payroll Administrator

The Payroll Administrator is responsible for all aspects of payroll processing, the daily activities of stock plan administration, and provides back-up support for the Accounts Payable team. The Payroll Administrator will ensure accurate and timely processing of semi-monthly and off-cycle payroll in Workday for approximately 200 multi-state employees, generate payroll accounting entries, ensure accurate tax calculation of employee stock option exercises and RSU vesting, process grants, and ensure timely and accurate payroll tax and stock government filings.  Additionally, this individual will routinely partner with others across multiple functions ensuring proper alignment with policies, controls and compliance with US GAAP. This position reports to the Senior Manager, Accounting and is based in Emeryville, CA.

Specific Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Vice President, Business Development / Licensing

The Vice President, Business Development / Licensing will be responsible for business development, partnering and alliance management activities, including supporting operations, as required, and conducting product/market evaluations outside of the United States. The ideal candidate will be a business-minded strategic and operational leader who will bring strong corporate transaction, alliance management, analytical, and general operations expertise to Adamas. This individual will lead our internal and external business development and partnering activities, and collaborate with key functions to achieve Adamas’ objectives.  This position will report to the Chief Business Officer and General Counsel.

Specific Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Vice President, Quality Assurance

The Vice President, Quality Assurance will be responsible for leadership and strategic direction to ensure  Adamas’s corporate  Quality Assurance activities.  The successful candidate will be responsible for all aspects of quality assurance including regulatory inspections, vendor management, quality systems clinical and preclinical compliance, disposition of commercial product and clinical supplies.  The Vice President of Quality Assurance will be based in Emeryville, California and report to the Chief Business Officer, General Counsel & Chief Compliance Officer.

The primary focus of this position is to inspire, support and maintain a culture committed to quality in Adamas’ business activities.  Specifically, this position with the quality team will be focused on ensuring the continued maintenance and continuous improvement of key GxP processes, systems and documentation to ensure adherence to our global regulatory obligations with respect to research, clinical development, manufacturing and the availability of clinical and commercial supplies.

Specific Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.