ADS-4101 is an investigational high-dose lacosamide, to be taken once-daily at bedtime. Lacosamide is an anti-epilepsy active ingredient previously approved by the U.S. Food and Drug Administration (FDA) and currently marketed by UCB as VIMPAT® (lacosamide).

Epilepsy affects an estimated 2.2 million Americans, of which 60% have partial onset seizures. Monotherapy treatment of partial seizures is effective in approximately 60% of patients, leaving the remainder of patients to require adjunctive treatment with one or more additional anticonvulsant therapies. There are limited data on the temporal distribution of seizures over the 24-hour day. However, data from published studies and from a study conducted by Adamas suggest that seizures occur in a diurnal pattern, characterized by a peak between 8 AM and 4 PM, and lowest between midnight and 8 AM. Thus, by matching the timing pattern of seizures to the concentration of the anti-epileptic drug, with a higher drug concentration during the day and lower drug concentration during the night, may enable improved seizure control.

Clinical studies of lacosamide have demonstrated dose limitations due to dizziness immediately following administration. We hypothesized the dizziness associated with higher doses might be in part attributed to the rapid initial rate-of-rise in drug concentration. Adamas scientists confirmed this time-dependent effect through in vivo modelling and pre-clinical experiments, showing that tolerability was dependent on rate -of-rise of drug concentration and not on maximum concentrations (Cmax).

We designed ADS-4101 to have an [attenuated/ tempered] initial rate-of-rise in lacosamide concentrations, to potentially improve the adverse event profile. This slow initial rise, enables a higher once-daily nighttime dose, resulting in a higher daytime concentration that may be more effective for patients then VIMPAT.

The data from a Phase 1 study of 24 healthy volunteers showed that a single 400 mg dose of ADS-4101 have improved tolerability compared to the equivalent dose of VIMPAT (lacosamide) immediate-release (IR) tablets. The data also demonstrated that ADS-4101 exhibited the desired pharmacokinetic properties, namely a reduced initial rate-of-rise and prolonged time to maximum drug concentration (Tmax) appropriate for nighttime dosing.

We are currently conducting a multi-dose Phase 1b study designed to evaluate the tolerability and pharmacokinetic profile of three ascending doses of ADS-4101 (up to 600 mg/day) taken once-daily at bedtime compared to ascending doses of twice daily VIMPAT tablets in 24 healthy volunteers. Topline data from the study is expected in the third quarter of 2017.

Associate Director, Commercial Finance (Financial Planning and Analysis)

The Associate Director, Commercial Finance (FP&A) is primarily responsible for providing financial leadership to the organization’s Commercial function. The role will focus on the analytics that support financial planning, budgets, forecasting, monthly close support, and project management. The role will be a hands-on resource to senior management, project/brand leads, and department heads. This position reports to the Sr. Director, FP&A and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Clinical Program Director

The Clinical Program Director plays a lead role in developing Adamas clinical operations team and infrastructure for a given project(s). (S)He will provide strategic input and drive the planning and execution for assigned clinical trials with direct responsibility for time, cost, quality and risk mitigation. This position is based in Emeryville, CA and reports to the VP, Clinical Operations.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Counsel / Senior Counsel, Healthcare Law

The Counsel / Senior Counsel, Healthcare Law, will support legal matters related to the strategy and execution of commercial, medical, and clinical activities. This position reports to the Assistant General Counsel and is expected to work closely with other members of the legal and compliance group, as well as executive, commercial, medical, regulatory, and clinical teams.  This position is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Desktop Engineer, Information Technology

The Desktop Engineer is responsible for developing, deploying, and managing end user’s systems security, automation, software deployment, software patch remediation and device management in addition to providing escalated helpdesk support to internal users. This position will be tasked with creating functional deliverables, such as; testing plans/scripts, creating training plans and on-boarding manuals, identifying gaps, and providing solutions to IT related matters. This position reports to the Senior Manager, IT Operations and is located in Emeryville, California.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Commercial Operations

The Director, Commercial Operations partners with the Commercial Organization to drive and measure performance by providing subject matter expertise, leadership and insights with a primary focus on Reporting, Incentive Compensation, and CRM/DW/MDM. This position reports to the Vice President, Commercial Operations and is based in Emeryville, CA.

Responsibilities:

Qualifications:

Competencies:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Development Regulatory Affairs

The Director, Development Regulatory Affairs ensures that regulatory expertise is provided for all investigational drug development programs to enable product registration. The incumbent will be an effective collaborator with the research, clinical research, clinical operations, pharmaceutical development, and quality departments. This position reports to the Vice President, Regulatory Affairs and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Drug Product Manufacturing

The Director, Drug Product Manufacturing will be responsible for managing manufacturing activities at contract manufacturers (CMOs) to support global markets. The position involves working with Pharmaceutical Development to transfer manufacturing processes, production scheduling, process troubleshooting and overseeing manufacture of commercial drug product. The successful candidate will work in a collaborative internal team environment as well as with external vendors to ensure manufacturing timelines are met. The candidate must have thorough understanding of major manufacturing processes and technical understanding of equipment used in solid dosage drug products. This position will be reporting to the Vice President, Manufacturing Operations and is based in Emeryville, California.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Nonclinical and Clinical Pharmacokinetics

The candidate will reside in the Research Department and will collaborate on project teams to provide key pharmacokinetic expertise to all stages of nonclinical and clinical development. In this capacity, the candidate will contribute to the design, execution, and analysis of nonclinical and clinical studies and the analysis and interpretation of pharmacokinetic data. The successful candidate will possess the relevant background and experience in pharmacokinetics in order to effectively execute program objectives. The candidate will be based in Emeryville, CA and will report to the Vice President, Research.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Promotional Regulatory Affairs

The Director, Promotional Regulatory Affairs ensures regulatory expertise is provided for all advertising and promotion related activities. The incumbent works is an effective collaborator with the commercial and legal departments. The position reports to the VP, Regulatory Affairs and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Director, Quality Assurance

The Director, Quality Assurance is responsible for all aspects quality assurance and GxP compliance. The Director, Quality Assurance will establish quality plans and policies and report to Quality Management on a regular basis on compliance activities and findings. This position will design, implement and maintain QA and compliance programs and infrastructure including a SOP system, training program, and perform internal and external audits. The Director, Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance in a GxP international regulatory environment. This position will serve as an in-house advisor on GxP compliance and report to the Vice President, Quality Assurance and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Executive Assistant to the CEO

Reporting to the Chief Executive Officer, the Executive Assistant will provide advanced administrative support to help ensure the smooth operations of the Executive Office. Specifically, the Executive Assistant will directly support the Chief Executive Officer (CEO), as well as the Chief Financial Officer (CFO). Successful candidates will be extremely well organized, excellent communicators, capable of effectively managing complex schedules, and working closely with other members of the Adamas Administrative team to coordinate senior management activities. The EA will also be the lead interface with the company Board of Directors as well as external partners, The Executive Assistant will be able to anticipate many of the needs of the team and will be proactive in the execution of those needs.  The position is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Manager / Senior Manager, Pharmaceutical Development

The Manager / Senior Manager, Pharmaceutical Development contributes to the drug product development process by developing formulations for preclinical and clinical evaluation.  It involves working collaboratively within a multidisciplinary framework within the organization and with external contract manufacturing organizations. This position reports to the Associate Director, Pharmaceutical Development and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Manager, Quality Systems

Manager, Quality Systems is responsible for managing the systems related to GxP compliance. This includes the daily administration tasks of the quality systems such as tracking, indexing, evaluating through metrics, and the management of the documents and records. This person will manage and facilitate quality system implementation, standardization, and maintenance in addition to serving as the Subject Matter Expert (SME) for the use of these systems. The quality systems at Adamas are a blend of manual and electronic records which include but are not limited to: Standard Operating Procedures (SOPs), forms, specifications, master and executed batch records, deviations, CAPA’s, complaints, validation and stability protocols, training records, staff CVs, job descriptions and other relevant GXP documents This position reports to the VP, Quality Assurance and is located in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Medical Director/ Senior Medical Director

The Medical Director / Senior Medical Director will be integrally involved in all aspects of clinical trial design and execution, including authoring of protocols, site initiation, and medical monitoring, as well as data interpretation and reporting. Position reports to Senior Vice President, Clinical Research and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

QA Document Control Specialist

The QA Document Control Specialist is responsible for initiating, maintaining, tracking, indexing and file retrieval of all Company GXP documents. The document control system at Adamas is a blend of a manual system which tracks documents that are then posted in SharePoint, and the use of an Electronic Document Management System (EDMS). Documentation includes, but is not limited to: Standard Operating Procedures (SOPs), forms, specifications, master and executed batch records, deviations, CAPA’s, validation and stability protocols, training records, and other relevant GXP documents. This position reports to the Manager, Quality Systems and is located in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Senior Director, Research

The candidate will lead a team of scientists to conduct nonclinical efficacy and safety studies in support of Adamas’ neurological diseases projects. In this capacity, the candidate will develop nonclinical strategies and oversee the design, execution, analysis, and reporting of the research components of discovery and development programs. The successful candidate will possess the relevant background and experience in neuroscience, and possess appropriate leadership skills, in order to effectively execute program objectives. The candidate will be based in Emeryville, CA and will report to the Vice President, Research.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Senior Vice President, Development Operations

The Senior Vice President, Development Operations is the Company’s research and development (R&D) operational expert and oversees the successful execution of all clinical and regulatory contributions to our new drug applications. The SVP will build and manage a highly functioning regulatory affairs and clinical operations departments. Ensures regulatory expertise is provided across the discovery, development, and commercial continuum. Ensures all Adamas development programs target a clearly defined goal (i.e., target product profile) and are filled with the results of well executed clinical trials within time, budget, and quality constraints. Owns the creation and implementation of all R&D dashboards. Partners with the heads of research, clinical research and medical affairs, as per guidance from the Chief Medical Officer. The incumbent reports directly to the CEO and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Manager, IT Applications

The Sr. Manager, IT Applications is responsible for providing strategy, technology guidance, implementation and support to Clinical, Manufacturing, Medical Affairs, Pharmaceutical Development, Product Development, Quality Assurance and Regulatory Affairs. Position will also oversee corporate content, document management and IT training. This is a hands-on role that will involve close collaboration with and active support of departmental leaders throughout the organization. This position reports to the VP, Information Technology and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Vice President, Clinical Operations

The Vice President, Clinical Operations is accountable for the consistently high performance of the Clinical Operations department, which oversees the execution of all Adamas clinical studies within time and cost constraints, ultimately resulting in high quality clinical trial data on all Adamas investigational products and marketed medicines. Responsible for hiring, leading / mentoring, and managing full time employees and consultants. This position is a peer to the heads of Research, Clinical Research, Regulatory Affairs and Medical Affairs. The incumbent is based in Emeryville and reports directly to the Senior Vice President, Development Operations.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Vice President, Corporate Communications

The Vice President, Corporate Communications at Adamas will lead the continued development and dissemination of the Adamas brand to internal and external stakeholders. With the CEO, this person will set Adamas’ communications strategy, develop brand, positioning and core messaging, build relationships with key channels, and effectively communicate about the Company to all internal and external constituencies. This person will work closely with the entire executive leadership team to craft and deliver content. Corporate Communications will work closely with Investor Relations to shape the message for the financial audience, and have a seat on the Brand teams, to ensure compatibility between the Corporate and Product Brands.  The Vice President, Corporate Communication will also be a main contact for all media, advocacy relationships and government affairs.  This position reports directly to the CEO, and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Vice President, Medical Affairs

The Vice President, Medical Affairs is responsible for the design and implementation of all medical affairs deliverables, including, but not limited to medical information, field medical science liaison team, medical affairs related collateral development, investigator independent studies, and medical education grants. The position reports to the Chief Medical Officer and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.