ADS-4101 is an investigational high-dose lacosamide, to be taken once-daily at bedtime. Lacosamide is an anti-epilepsy active ingredient previously approved by the U.S. Food and Drug Administration (FDA) and currently marketed by UCB as VIMPAT® (lacosamide).

Epilepsy affects an estimated 2.2 million Americans, of which 60% have partial onset seizures. Monotherapy treatment of partial seizures is effective in approximately 60% of patients, leaving the remainder of patients to require adjunctive treatment with one or more additional anticonvulsant therapies. There are limited data on the temporal distribution of seizures over the 24-hour day. However, data from published studies and from a study conducted by Adamas suggest that seizures occur in a diurnal pattern, characterized by a peak between 8 AM and 4 PM, and lowest between midnight and 8 AM. Thus, by matching the timing pattern of seizures to the concentration of the anti-epileptic drug, with a higher drug concentration during the day and lower drug concentration during the night, may enable improved seizure control.

Clinical studies of lacosamide have demonstrated dose limitations due to dizziness immediately following administration. We hypothesized the dizziness associated with higher doses might be in part attributed to the rapid initial rate-of-rise in drug concentration. Adamas scientists confirmed this time-dependent effect through in vivo modelling and pre-clinical experiments, showing that tolerability was dependent on rate -of-rise of drug concentration and not on maximum concentrations (Cmax).

We designed ADS-4101 to have an [attenuated/ tempered] initial rate-of-rise in lacosamide concentrations, to potentially improve the adverse event profile. This slow initial rise, enables a higher once-daily nighttime dose, resulting in a higher daytime concentration that may be more effective for patients then VIMPAT.

The data from a Phase 1 study of 24 healthy volunteers showed that a single 400 mg dose of ADS-4101 have improved tolerability compared to the equivalent dose of VIMPAT (lacosamide) immediate-release (IR) tablets. The data also demonstrated that ADS-4101 exhibited the desired pharmacokinetic properties, namely a reduced initial rate-of-rise and prolonged time to maximum drug concentration (Tmax) appropriate for nighttime dosing.

We are currently conducting a multi-dose Phase 1b study designed to evaluate the tolerability and pharmacokinetic profile of three ascending doses of ADS-4101 (up to 600 mg/day) taken once-daily at bedtime compared to ascending doses of twice daily VIMPAT tablets in 24 healthy volunteers. Topline data from the study is expected in the third quarter of 2017.

Director, Corporate and Product Communications

The Director, Corporate and Product Communications at Adamas will support the development and execution of Adamas’ Corporate and Product communications strategies, develop positioning and core messaging, execute tactically, build relationships with key channels, and effectively communicate about the Company and brands to constituencies. Reporting to the VP, Communications and Engagement this person will be a main contact for advocacy relationships, forging partnerships and leading on strategic collaborations. The Director will work closely with Product Brand team(s) to develop and and execute effective communications, media and PR activities to support brand strategy and positioning, including corporate communications around scientific and medical milestones.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Neurology Account Specialist, Atlanta GA

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Neurology Account Specialist, Chicago IL

The Neurology Account Specialist (NAS) engages with targeted customers and effectively communicates the value proposition for GOCOVRI for approved indications. The NAS achieves this through use of strong engagement skills, exemplary product, disease state and market knowledge; and stellar account planning involving all strategic stakeholders within a defined sales territory.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

 

Senior Accountant

The Senior Accountant is responsible for performing daily accounting operations including preparation of journal entries, account reconciliations, financial statement analysis and ad hoc projects. The Senior accountant will be responsible for cash, payroll, and equity related accounting. The Senior Accountant will also manage and coordinate the payroll performed by our third-party service provider to ensure accurate and timely processing of payroll in Workday for approximately 200 multi-state employees. Additionally, this individual will routinely partner with others across multiple functions ensuring proper alignment with policies, internal controls (SOX 404) and compliance with US GAAP. This position reports to the Senior Manager, Accounting and is based in Emeryville, CA.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, Commercial IT

The Senior Director, Commercial IT is responsible for serving as strategic interface with Commercial and Medical affairs organizations. Individual in this role is responsible for developing relationships with business stakeholders and serve as trusted technology advisor in addition to leading Commercial IT function and staff. Senior Director is required to maintain an understanding of Pharmaceutical commercial business processes, Commercial/Medical data & technology roadmap, design solutions, implement systems, and manage operational support for commercial IT systems. This person will be responsible for understanding and coordinating with the other IT business partners, especially across Commercial IT teams around other initiatives aligned to common capabilities such as business intelligence and master data management to deliver value added services in various business function.

Individual in this role will represent the technology organization as the primary point of contact with the Commercial & Medical Affairs organization and accountable for all technology related issues and opportunities and address them thru the engagement and support of cross functional team.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.

Sr. Director, IT (Infrastructure, Operations and Security)

The Sr. Director, IT is a senior level individual to lead and execute the strategy for IT infrastructure, help desk customer support, network operations and security. Individual in this role is responsible for leading IT function and staff that provides the following support to the enterprise: helpdesk and customer service, data center operations, security operations, server OS operations, network operations; storage operations and system maintenance and monitoring. He/She has overall accountability for team decisions, management, and results. Provides direction, coaches, develops, and mentors leaders within the Helpdesk and Network teams and outside those groups in addition to hands-on support as needed. He/she is an advocate for Adamas’ total information security needs and is responsible for the development and delivery of a comprehensive risk based information security strategy to optimize the security posture of the company.

Responsibilities:

Qualifications:

To apply for this position please send your resume to hr@adamaspharma.com with the job title  in the subject line. Principals only, no recruiters please.

Adamas is an Equal Opportunity Employer

The above statements are intended to describe the general nature and level of work being performed by people assigned to this job. This description is not intended to be construed as an exhaustive list of all the responsibilities, duties and skills required.