Publications

• Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro.
  Nguyen JT, Hoopes JD, Le MH, Smee DF, Patick AK, Faix DJ, Blair PJ, de Jong MD, Prichard MN, Went GT.
  PLoS One. 2010 Feb 22;5(2):e9332.

• Rapid quantification of single-nucleotide mutations in mixed influenza A viral populations using allele-specific mixture analysis.
  Liu CM, Driebe EM, Schupp J, Kelley E, Nguyen JT, McSharry JJ, Weng Q, Engelthaler DM, Keim PS.
  J Virol Methods. 2010 Jan;163(1):109-15. Epub 2009 Sep 15.

• Triple Combination of Oseltamivir, Amantadine, and Ribavirin Displays Synergistic Activity against Multiple Influenza Virus Strains In Vitro
  Jack T. Nguyen, Justin D. Hoopes, Donald F. Smee, Mark N. Prichard, Elizabeth M. Driebe, David M. Engelthaler, Minh H. Le, Paul S. Keim, R. Paul Spence, and Gregory T. Went.
  Antimicrobial Agents and Chemotherapy, Oct. 2009, p. 4115–4126.

• Modeling amantadine treatment of influenza A virus in vitro.
  Beauchemin CA, McSharry JJ, Drusano GL, Nguyen JT, Went GT, Ribeiro RM, Perelson AS.
  J Theor Biol. 2008 Sep 21;254(2):439-51. Epub 2008 Jul 23.

Presentations

• Gross M, Le M, Smee D, Barnard D, Patick A, Nguyen J. "The triple combination antiviral drug (TCAD) regimen of amantadine, ribavirin, and oseltamivir is highly efficacious against susceptible and resistant influenza virus strains in mouse treatment models." 23rd International Conference on Antiviral Research, San Francisco, April 25-28, 2010.

• Nguyen, J. "The triple combination of amantadine, ribavirin, and oseltamivir is highly efficacious against resistant influenza A virus infection in mice and suppresses the generation of resistant influenza A viruses in vitro." XII International Symposium on Respiratory Virus Infection, Taipei, Taiwan, March 11-14, 2010.

• Nguyen J, Hoopes J, Smee D, Le M, Patick A, de Jong M, Went G, Faix D, Blair P, and Prichard M. "Triple combination of amantadine, ribavirin, and oseltamivir restores in vitro acitivity of antiviral drugs against resistant influenza viruses." Oral presentation, 49th Annual InterScience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 12-15, 2009.

• Nguyen, J., Hoopes, J., Smee, D., Wong, M-H, Hurst, B, Driebe, E., Engelthaler, D., Keim, P., Went, G. "Triple combination therapy is highly synergistic for Influenza A infection." 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, DC, October 26, 2008.

• Smee D, Nguyen J, Wong M, Driebe E, Engelthaler D, Keim P, and Went G. "Triple combination therapy for the treatment of influenza." Oral presentation, X International Symposium on Respiratory Virus Infection, Singapore, February 28-March 2, 2008.

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