Adamas was founded to approach drug development in an extremely practical way. Adamas first targets large market opportunities where novel formulations and combination therapy offers significant advantages over existing medicines. Adamas' research and development platform allows the Company to discover new drug formulations and combinations with mechanisms that work together in an additive or synergistic manner and that can be precisely formulated in fixed-dose combinations to achieve optimal performance. By working with well-characterized and widely studied drugs, Adamas scientists reduce the uncertainties typically associated with the development of new chemical entities. The Company's resulting product candidates (called "Advantaged Therapeutics") hold advantages over other approaches in terms of:

• Enhanced efficacy through modified pharmacokinetic profile and/or synergistic activity;
• Improved tolerability;
• Improved convenience; and
• IP protection.

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